È ispirato ai precedenti programmi di Fiorello, Edicola Fiore (2011-2017), Viva RaiPlay e Viva Asiago10 (2019). We are now using these methods for personalized oncology by studying the structural conformation of neo-antigens presented within the MHC context or the structural TCR repertoire selected against such neo-antigens. Viva Rai2 è un programma televisivo italiano di genere varietà, satirico e rotocalco, ideato e condotto da Rosario Fiorello con la partecipazione di Fabrizio Biggio, in onda dal 5 dicembre 2022 nella fascia mattutina di Rai 2. Since our approach is based on the laws of physics, its universal nature allows direct application to other proteins or complexes of interest like, for example, signaling domains. We use molecular dynamics and free energy simulations to study key proteins like the TCR-Peptide-MHC complex and to improve relevant biological properties such as the on-rate, off-rate or the affinity. Structure-based protein design has also been a strong interest of our group. Recently, we have launched the Swiss Personalized Oncology project that aims at providing a seamless web interface to access these tools for the clinicians making decisions within molecular tumor-boards. Our algorithms are now being used for personalized oncology, where the impact of somatic mutations on specific targeted therapies is evaluated. Our program starts with computer aided drug design, organic synthesis, soluble and cellular tests, all the way to proof of concept studies in mouse models. Current projects include IDO for which several nano-molar compounds have been generated as well as STING. Her first studio album, Riflessi di me, was released in 2012. Aged sixteen at the time, she was the youngest winner in that show's history. Structure-based drug designĪs part of a long-lasting interest of our group in structure based drug design, we are pursuing several projects to design high affinity small molecule inhibitors for important targets in oncology and, most importantly, immuno-oncology. Prior to Eurovision, Michielin won the fifth season of Italy's X Factor in 2011, where she was mentored by Simona Ventura. Some of these developments are conducted in collaboration with the Swiss Data Science Center (SDSC). In addition, we are also developing techniques to make use of the existing body of knowledge (Pubmed, Onco-KB, TCGA, …) to prioritize some branches of the decision trees. We are actively developing methodologies to provide interpretable machine learning results that pinpoint to the essential aspects leading to the proposed classification by the algorithm. In particolare, si tratta di Marco Mengoni (Italia 2013 e 2023) e Diodato (Italia 2020, sebbene non abbia mai potuto calcare il palco) i due coinvolti nei premi più importanti della scena. Selecting the best treatment option for patients based on large –omics data sets require cutting edge machine learning algorithms. Sono due i rappresentanti dell’Italia all’Eurovision Song Contest del presente e del passato che sono candidati ai David di Donatello per il 2023. The following projects are conducted in close collaboration with Zoete Lab.
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